Mo was born Maureen Anne Collins and raised in Minneapolis, Minnesota, where she started her improv and sketch career with Dudley Riggs BNW in Minneapolis. In 1998 she moved to Los Angeles, where she landed "MadTV", giving birth to many unforgettable characters, such as Lorraine, Stuart's Mother, and Trina. She has since built up her credits with hit shows such as "Arrested Development", "Curb Your Enthusiasm", and "Parks and Recreation" as scandal-wrangler Joan Callamezzo; and in "40-Year-Old Virgin" as Gyna, and seasons 4-7 of "Fear the Walking Dead" as Sarah Rabinowitz. She is a woman of many voice in animation, notably on Netflix's "F is For Family," for which she earned her first Emmy nomination in 2017. Mo is married to actor Alex Skuby and has one son. She enjoys doing stand-up/improvisation and is an avid animal advocate.