Facing an existential threat that could bring down the Crime Lab, a brilliant team of forensic investigators must welcome back old friends and deploy new techniques to preserve and serve justice in Sin City (aka Las Vegas, Nevada).

Expecting their first child, a Mexican-American couple move to a migrant farming community in 1970's California where strange symptoms and terrifying visions threaten their new family.

Daimon and Ana Helstrom are the son and daughter of a mysterious and powerful serial killer. The siblings have a complicated dynamic as they track down the terrorizing worst of humanity - each with their attitude and skills.